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Receiving its first major renovation in 51 years, the dairy microbiology building was dedicated as the Alfred Dairy Science Hall in October 2011. It is home to the Department of Dairy and Food Science and the Department of Biology and Microbiology.

ADRDL is one of fewer than 40 veterinary diagnostic laboratories accredited by the American Association of Veterinary Laboratory Diagnosticians. The building constructed in 1993 houses the Department of Veterinary and Biomedical Sciences.

The Animal Resource Wing is the core animal facility on campus.

Built in 1977 at a cost of 4 million dollars, the Animal Science Complex is comprised of three units: the Animal Science Arena, the Meat Lab and research laboratories.

The Avera Health and Science Center opened July 2010 and features 97,000 square feet of teaching, laboratory and office space as well as 48,600 square feet of research laboratory space.

The Chicoine Architecture, Mathematics and Engineering Hall is a part of the Jerome J. Lohr College of Engineering. Located on the southwest side of campus, the 62,000-square foot building has three floors.

The Cow-Calf Education and Research Facility was completed in 2016 and is used by the College of Agriculture, Food and Environmental Sciences and the Department of Animal Science.

Built in 1957, the building is named after Harold M. Crothers, thrice acting president of then South Dakota State College (1946-1947, 1951 and 1957-1958) and former dean of the College of Engineering. The cost of the structure was approximately $850,000.

The Dakota Lakes Research Farm focuses on both irrigated and dryland crop research. The farm is managed as a no-till farm. Nearly one-third, 240 of the 840 acres, is devoted to irrigation.

Daktronics Engineering Hall houses two departments, electrical engineering and computer science and physics. The facility boasts four floors and 29,000 square feet of space.